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Cyclic GMP-AMP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cyclic GMP-AMP Synthase (7) Endogenous Metabolite (3) IFNAR (1) IRAK (1) STING (4)
By Research Areas:	Inflammation/Immunology (9) Metabolic Disease (2)

12

Inhibitors & Agonists

3

Natural
Products

2

Recombinant Proteins

Targets Recommended: Cyclic GMP-AMP Synthase AMPK HCN Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

cGAMP 5+ Cited Publications Cyclic GMP-AMP; 3',3'-cGAMP	STING	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

cGAMP disodium 5+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

cGAMP diammonium 5+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	STING Endogenous Metabolite	Inflammation/Immunology
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

2',3'-cGAMP sodium 5+ Cited Publications 2'-3'-Cyclic GMP-AMP sodium	Endogenous Metabolite STING IFNAR	Metabolic Disease
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm .

2',3'-cGAMP 5+ Cited Publications 2'-3'-Cyclic GMP-AMP
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm .

G140 1 Publications Verification	Cyclic GMP-AMP Synthase	Inflammation/Immunology
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC₅₀s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity .

cGAS-IN-1	Cyclic GMP-AMP Synthase	Inflammation/Immunology
cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC₅₀s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity .

HY-160546

cGAS-IN-2

Cyclic GMP-AMP Synthase Inflammation/Immunology

cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with IC₅₀ of 0.01512 μM for h-cGAS .

PF-06928215 3 Publications Verification	Cyclic GMP-AMP Synthase	Inflammation/Immunology
PF-06928215 is a *cGAS (cyclic* GMP-AMP Synthase) inhibitor with an IC₅₀ of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (K_d**) .

G150 3 Publications Verification	Cyclic GMP-AMP Synthase	Inflammation/Immunology
G150 is a highly selective *human cyclic* GMP-AMP synthase (h-cGAS) inhibitor with an IC₅₀** of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory .

IRAK4-IN-4 1 Publications Verification	IRAK Cyclic GMP-AMP Synthase	Inflammation/Immunology
IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC₅₀ of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC₅₀ of 2.1 nM .

RU.521 Maximum Cited Publications 21 Publications Verification RU320521	Cyclic GMP-AMP Synthase	Metabolic Disease
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC₅₀ of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) .

Species:	Human (2)
Tag:	His (2) SUMO (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	cGAS Protein, Human (His) 1 Publications Verification Cyclic GMP-AMP synthase; cGAMP synthase; h-cGAS; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1; MB21D1; C6orf150	Human	E. coli
	The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His) is the recombinant human-derived cGAS protein, expressed by E. coli , with C-6*His labeled tag. The total length of cGAS Protein, Human (His) is 522 a.a., with molecular weight of ~58.9 kDa.

	cGAS Protein, Human (His-SUMO) C6orf150; cGAMP synthase; cGAS; CGAS_HUMAN; cGMP Synthase; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; Mab-21 domain-containing protein 1; MB21D1; MGC131892; MGC142166; MGC142168; OTTHUMP00000016743; OTTHUMP00000039330; protein MB21D1; Uncharacterized protein C6orf150	Human	E. coli
	The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His-SUMO) is the recombinant human-derived cGAS protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of cGAS Protein, Human (His-SUMO) is 362 a.a., with molecular weight of ~58.3 kDa.

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